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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Bayesian tool for methylation analysis ： ウィキペディア英語版 Bayesian tool for methylation analysis Bayesian tool for methylation analysis, also known as BATMAN, is a statistical tool for analyzing methylated DNA immunoprecipitation (MeDIP) profiles. It can be applied to large datasets generated using either oligonucleotide arrays (MeDIP-chip) or next-generation sequencing (MeDIP-seq), providing a quantitative estimation of absolute methylation state in a region of interest.〔Down, T.A. et al. A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. ''Nature Biotechnology'' 26, 779–85 (2008).〕 ==Theory== MeDIP (methylated DNA immunoprecipitation) is an experimental technique used to assess DNA methylation levels by using an antibody to isolate methylated DNA sequences. The isolated fragments of DNA are either hybridized to a microarray chip (MeDIP-chip) or sequenced by next-generation sequencing (MeDIP-seq). While this tells you what areas of the genome are methylated, it does not give absolute methylation levels. Imagine two different genomic regions, ''A'' and ''B''. Region ''A'' has six CpGs (DNA methylation in mammalian somatic cells generally occurs at CpG dinucleotides〔Lister, R. ''et al''. Human DNA methylomes at base resolution show widespread epigenomic differences. ''Nature'' 462, 315–22 (2009).〕), three of which are methylated. Region ''B'' has three CpGs, all of which are methylated. As the antibody simply recognizes methylated DNA, it will bind both these regions equally and subsequent steps will therefore show equal signals for these two regions. This does not give the full picture of methylation in these two regions (in region ''A'' only half the CpGs are methylated, whereas in region ''B'' all the CpGs are methylated). Therefore, to get the full picture of methylation for a given region you have to normalize the signal you get from the MeDIP experiment to the number of CpGs in the region, and this is what the Batman algorithm does. Analysing the MeDIP signal of the above example would give Batman scores of 0.5 for region ''A'' (i.e. the region is 50% methylated) and 1 for region ''B'' (i.e. The region is 100% methylated). In this way Batman converts the signals from MeDIP experiments to absolute methylation levels. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Bayesian tool for methylation analysis」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.